Effects of Danshen injection on Differentiation of Neural Stem Cel s in Rats with Cerebral Infarction
Lin Hui
Yang Wanzhang
Abstract：Objective To investigate the effects of Danshen injection on differentiation of neural stem cel s (NSCs)in bilateral ventri-cle subventricular zone(SVZ)in rats with cerebral infarction.Methods The 24 successful middle cerebral artery occlusion(MCAO) adult male Sprague Dawley (SD)rat models were randomly devided into a Danshen injection group,a saline group. In each group, 12 MCAO rats were randomly al ocated into groups(6 rats in each subgroups).Neurological deficits were evaluated using the modified neurological severity score(mNSS)before treatment and on the 7 th,14 th day after treatment.Another randomly selected 12 normal rats served as sham operation group. BrdU/NeuN,NeuN/GFAP double positive cel s were detected by immunofluorescence tech-niques.Results After 7 d,14 d treatment,Danshen injection group rats’mNSS was decreased compared with saline group,the difference was statistical y significant(P<0.05);each time,the number of BrdU+ /NeuN+ cel s in Danshen injection group were in-creased than the other two groups,the difference was statistical y significant(P<0.05).Conclusion Danshen injection can promote differentiation of NSCs into neurons and improve neurological function after cerebral infarction,play a positive role in neural remodeling.
Keywords：cerebral infarctionDanshen injectiondifferentiationneurons
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 484-486 )