The Reference Value of Neuron specific Enolase for the Diagnosis of Cerebral Infarction and the Differentiation of Traditional Chi-nese Medicine Syndrome in Hypertensive Patients
Wu Aiming
Zhao Mingjing
Zhang Dongmei
Gao Yonghong
Nie Bo
Lou Lixia
Wang Shuoren
Abstract：Objective To study the reference value of neuron specific enolase (NSE)for the diagnosis of cerebral infarction and the differentiation of traditional Chinese medicine (TCM)syndrome in hypertensive patients.Methods Clinical data of 174 cases of pa-tients with essential hypertension were col ected.The serum concentration of NSE was detected by Enzyme linked immunosorbent assay (ELISA).The clinical value,the Optimal Operating Point (OOP)and discriminatory power of NSE to diagnose cerebral infarc-tion were determined by using the Receiver Operating Characteristic (ROC)curves in hypertensive patients.Then the correlation be-tween NSE and TCM syndromes were analyzed.Results Compared with non infarction group,the serum concentration of NSE was increased significantly in hypertension complicated with cerebral infarction group (4.49μg/L± 1.23μg/L vs 3.20μg/L± 2.01μg/L, P<0.01).The area under the curve was 0.785 with a certain accuracy (P<0.01).The OOP of NSE was determined and interpreted at 4.27μg/L,corresponding to 67.6% sensitivity and 81.8% specificity.Compared with non phlegm syndrome group,the serum con-centration of NSE was increased significantly in phlegm syndrome group (4.48μg/L± 1.31μg/L vs 3.23μg/L± 2.00μg/L,P<0.01). Correlation analysis showed that there was a positive correlation between NSE and phlegm syndrome (r= 0.385,P<0.01).Con-clusion NSE has some reference value for the diagnosis of cerebral infarction and the differentiation of phlegm syndrome in hyper-tensive patients.
Keywords：hypertensionneuron specific enolasecerebral infarctiontraditional Chinese medicine syndromes
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 437-440 )