Impacts of Tea Polyphenols on Pulmonary Artery Pressure and the Inhibition of Apoptosis Proteins in Rats with Hypoxia Induced Pul-monary Hypertension
Abstract：Objective To investigate the effects of tea polyphenols(TP) on pulmonary artery pressure and the inhibition of apoptosis proteins in rats with hypoxia induced pulmonary hypertension.Methods Twenty four Sprague Dawley SD rats were randomly di-vided into three groups (n= 8 in each group):Normal control group(C),hypoxia group(H)and TP group.Before the hypoxia state, the rats in TP group were given TP 200 mg/(kg· d)each day.The rats in C group and H group were given normal saline.Then the rats in TP group and H group kept in atmospheric pressure with intermittent hypoxia for 8 hours a day,6 days weeks.After 4 weeks, mean pulmonary artery pressure mPAP,right ventricular hypertrophy index RVHI,wal thickness of smal pulmonary artery were com-pared.Apoptosis of pulmonary arterial smooth muscle cel s(PASMCs)and the mRNA expression of X linked inhibitor of apoptosis protein XIAP and Livin were also detected.Results Compared with C group,mPAP,RVHI and wal thickness of smal pulmonary ar-tery were increased in H group (al P<0.01),decrease in smooth muscle cel apoptosis (P<0.01),and increase in XIAP mRNA expression(P<0.01).There were decrease in mPAP,RVHI,wal thickness of smal pulmonary artery in TP group compare with H group,increase in smooth muscle cel apoptosis (P<0.05)and reduction in XIAP mRNA expression (P<0.05)in TP group.How-ever,Livin mRNA expression was not significantly different in three groups(P>0.05).Conclusion TP ameliorate hypoxia induced pulmonary hypertension in rats,its mechanism may be related to inhibit XIAP but not Livin expression,promoting the apoptosis of PASMCs.
Keywords：pulmonary hypertensionapoptosisX linked inhibitor of apoptosis proteintea polyphenols
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 430-433 )