Influence of Hypertension on the Expression of MAG and MBP in the Sciatic Nerve in Rats with Diabetic Peripheral Neuropathy
Lü Hengjuan
Zhang Dawei
Li Wenyuan
Wang Ying
Abstract：Objective To investigate the effects of hypertension(HTN)on the expression of myelin associated glycoprotein (MAG) and myelin basic protein(MBP)in the sciatic nerve in rats with diabetic peripheral neuropathy(DPN).Methods The rats were randomly di-vided into normal group,DPN group and HTN+DPN group.After 4 weeks of modeling,the blood sugar,blood pressure and conduc-tion velocity of sciatic nerve were measured,the mRNA expression of MBP and MAG in the sciatic nerve was detected by RT PCR. Results After 4 weeks of modeling,compared with normal group,the blood sugar were increased in DPN group and HTN+DPN group,while the conduction velocity of sciatic nerve was decreased,the mRNA expression of MAG and MBP in sciatic nerve were in-creased (P<0.01).Compared with DPN group,the blood pressure were increased in HTN+DPN group,and the conduction velocity of sciatic nerve was decreased,the mRNA expression of MAG was increased and the expression of MBP was decreased in sciatic nerve (P<0.01).Conclusion Hypertension can contribute to worsening of DPN by elevating MAG and decreasing MBP in sciatic nerve,and inhabiting myelination.
Keywords：hypertensiondiabetic peripheral neuropathymyelin associated glycoproteinmyelin basic protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 188-190 )