Study on Mechanisms with Anti arrhythmic Effects of Yiqi Fumai Mixture
Li Haowa
Wu Qian
Shi Xiaolu
Sun Mingjie
Lin Qian
Abstract：Objective To investigate the anti arrhythmic mechanisms with Yiqi Fumai mixture(YFM) by the patch clamp technique. Methods Using the col agenase method in acutely isolated rat left ventricular myocytes,and using patch clamp techique,to record the action potential of ventricular myocytes.Results Before isoprenaline(Iso)perfusion,compared with the control group,the Chi-nese medicine(CM) group could significantly extend action potential duration(APD),APD50 and APD90 (P<0.05).After Iso perfu-sion,the control group and the CM group could significantly extend APD (P<0.05 or P<0.01),and the control group also could significantly extend APD50 and APD90 (P<0.01).After Iso perfusion,compared with the control group,the CM group could signifi-cantly shortening APD,APD50 and APD90 (P<0.01).Conclusion It suggests that YFM can against the prolongation of APD caused by Iso,maybe related to the inhibiton of the late plateau Ca2+ current and repolarization K+ current.
Keywords：arrhythmiaYiqi Fumai mixtureaction potentialpatch clampisoprenaline
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 132-134 )