Effect of B type Natriuretic Peptide Post conditioning on Myocardial Ischemia reperfusion
Huang Xingyue
Hu Gangying
Huang Tingting
Xie Qing
Li Dan
Hu Xiaorong
Jiang Hong
Abstract：Objective To explore the effect of B type natriuretic peptide (BNP)preconditioning on myocardial ischemia reperfusion (I/R)injury and the expression of high mobility group box 1 protein (HMGB1)in rats.Methods Anesthetized male rats were ische-mia for 30 min,and then were treated with BNP in 15 min before reperfusion until the end of reperfusion,and fol owed by reperfusion for 4 hours.Lactate dehydrogenase (LDH),creatine kinase (CK),tumor necrosis factor α(TNF α),interleukin 6(IL 6)and in-farct size were measured.HMGB1 expression was assessed by immunoblotting.Results The Results showed that treatment of BNP post conditioning could significantly decrease the infarct size and the levels of LDH and CK after 4 h reperfusion (al P<0.05). BNP post conditioning could also significantly inhibit the increases of TNF αand IL 6 (both P<0.05).Meanwhile,BNP post conditioning could significantly inhibit HMGB1 expression induced by I/R.Conclusion The present study suggested that post con-ditioning of BNP could protect against myocardial I/R injury which might be associated with inhibiting HMGB1 expression.
Keywords：myocardial ischemiaB type natriuretic peptidepost conditioningreperfusionhigh mobility group box 1 protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 55-57 )