Study of Peripheral Blood CD4+ CD25+Foxp3+Treg Cel in Patients with Coronary Heart Disease and Chronic Heart Failure
Wang Huan
Hu Yuanhui
Wei Yi
Jia Dailin
Du Bai
Abstract：Objective To observe the immune function and plasma N terminal pro B type natriuretic peptide (NT proBNP)lev-els,and to evaluate the state of immune activation in in patients with coronary heart disease(CHD)and chronic heart failure(CHF). Methods From August 2013 to February 2014 in department of cardiology of Guang’anmen hospital of traditional Chinese academy, a total of 125 in patients,of whom 93 patients with CHF,32 patients with non heart failure were chosen.The level of plasma NT proB-NP was determined by chemiluminescence immunoassay method.The peripheral blood CD4+ CD25+Foxp3+Treg cel ratio was meas-ured by flow cytometry.Results The levels of plasma NT proBNP in patients with CHF were higher than that in patients with non heart failure.The peripheral blood CD4+CD25+Foxp3+Treg cel s in patients with CHF was lower than that in patients with non heart failure.Conclusion There is the presence of immune activation state in patients with CHF and the levels of plasma NT proBNP increase with increasing New York Heart Association (NYHA)functional class.
Keywords：coronary heart diseasechronic heart failureN terminal pro B type natriuretic peptideCD4+ CD25+ Foxp3+ Treg cel s
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 33-36 )