Effect of Xinyi Capsule on No Reflow After Reperfusion of Acute Myocardial Infarction in Rabbits

doi:10.3969/j.issn.16721349.2014.12.047

Abstract：Objective To investigate the effect of Xinyi capsule(XYC)on no reflow(NR)after reperfusion of acute myocardial infarction(AMI)in rabbits.Methods Ninety four rabbits were enrol ed in this study.We randomly al ocated 80 rabbits and divided them into 5 groups randomly(n= 16),model group,positive drug group(Tirofiban 60μg/kg),XYC high dose group,XYC medium dose group,XYC low dose group(4.0 g,2.0 g,1.0 g crude drug /kg).14 rabbits were classified as sham operation group.After 5 days of intragastric administration with drug,AMI ischemia reperfusion model was created by ligating proximal left circumflex coronary ar-tery for 3 hours,and fol owed by myocardial ischemia reperfusion for 1 hour.Recordings of electrograms before interventional oper-ation and after reperfusion of AMI were performed,the degree of J point elevation were compared among the recordings;after reper-fusion of AMI,left ventricular hemodynamic parameters were measured by PowerLab biological signal col ection and processing sys-tem;the degree of NR were recorded by the method of vital staining with Evan’s blue and Thioflavin S.Results Compared with the model group,the degree of NR was significantly decreased at 38.1%,24.5%,19.7% in XYC high dose group,medium dose group, low dose group,respectively(P<0.05 or P<0.01).After reperfusion of AMI,the J point of the electrogram lowered significantly. LVSP,HR,±dp/dtmax increased significantly while LVEDP reduced significantly(P<0.05 or P<0.01).Conclusion XYC could pre-vent and treat the NR phenomenon resulted from reperfusion of AMI in rabbits to some degree.