Effect of Total saponins of Panax No tognseng Injection on the Expression of Nogo A/Ngr/Rhoa Signaling Regulation Pathway in Hippocampus CA1 in Rats with Middle Cerebral Artery Occlusion
Abstract：O bjective To study the effect o f to ta lsaponins o f panax no tognseng(PNS) injection on the rem o ldability and pro tec-tive m echanism in hippocam pus CA1 in ra ts w ith m iddle cerebra l artery occlusion (MCAO). M e thods The Y27632 g roup,PNS and Y27632 g roup and the contro lg roup w ere taken out random ly from a l SPF S prague D aw ley ra ts. A l o f the ra ts w ere used to estab-lish MCAO m ode l by im proving Longa M e thod except to the contro l g roup. Acco rding to Longa sco res and w e ights the successful m ode led and un g roup ra ts w ere random ly divided into m ode lg roup,PNS g roup and nim odipine(NP) g roup.A l o f ra ts w ere execu-ted 7 days after opera tion. The genera l sta te, w e ight and neuro log ica l function sco re o f the ra ts w ere assessed da ily.The pa tho log i-ca l and m o rpho log ica l and the expression o fNogo A, NgR1 and RhoA in hippocam pus CA1 w ere de tected.Results The expres-sion o fNogo A, NgR1 and RhoA in m ode l g roup w ere m o re than the contro l g roup P < 0.01). The expression o f Nogo A, NgR1 and RhoA in PNS g roup and the expression o fNgR1 and RhoA in PNS and Y27632 gourp w ere less than the modelgroup( P < 0.05 or( P< 0.01). The expression o fRhoA in Y27632 g roup w ere low er than the m ode lg roup( P < 0.01). Conclusion The PNS injection has the sam e effects as Y27632 and regula tes bo th the upstream and dow nstream o fNogo A /NgR1/RhoA signa ling pa thw ay, so it can enhance the recovery o f hippocam pus CA1 neuro log ica l function o f the MCAO ra ts.
Keywords：focalcerebral infarctionPanax NotognsenghippocampusneuroremodelingNogoA
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1370-1373 )