Clinical Value of Serum Uric Acid in Patients with Suspected Coronary Artery Disease
Tao Qin
Chen Jun
Zhang Yuqing
Abstract：O bjective To explo re the clinica l va lue o f serum uric acid (SUA) in pa tients w ith co ronary artery disease (CAD). M e thods There w ere 229 consecutive pa tients w ith suspected CAD w ho had undergone co ronary ang iog raphy. Pa tients w ere divid-ed into non CAD g roup o r CAD g roup acco rding to the results o f co ronary artery stenosis. The serum uric acid leve l and o ther pa-ram e ters w ere com pared be tw een tw o g roups. Results There w ere 161 pa tients w ith CAD. SUA w as higher in pa tients w ith CAD com pared w ith cases w ithoutCAD ( 5.5m g /dL± 1.0m g /dL vs. 5.2m g /dL± 1.0m g /dL, P = 0.004). SUA w as associa ted w ith signif-icantly severity o fCAD ( P = 0.002). After adjusting fo r significant confounding facto rs including age, diabe tes, sm oking, cho lestero l, and m e tabo lic syndrom e (M S), SUA w as no t an independent risk facto r o f CAD ( P = 0.151). Based on a subg roup ana lysis, SUA w as m o re close ly associa ted w ith CAD in w om en than in m en, and in the highest quartile ( ≥ 6.4m g /dL) than in the first quartile (<4.8 m g /dL). how ever,these results w ere no t significant( P = 0.062,P = 0.075,respective ly). In m ultivaria te reg ression ana lysis, the m ost im po rtant de term inant o f SUA w as M S, w hich w as strong ly associa ted w ith CAD. Conclusions In pa tients w ith suspected CAD, SUA is no t an independent risk facto r fo r CAD and itm ay be m ere ly a m arker o f insulin resistance.
Keywords：coronary artery diseaseuric acidcoronary angiographymetabolic syndrome
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1316-1319 )