Systematic Assessment of Xinglou Chengqi Decoction for Treatment of Acute Stroke
Lang Yi
Zou Yihuai
Abstract：O bjective The objective w as to system a tica ly assess cura tive effect and security of X ing lou Chengqi decoction (XCD) fo r trea tm ent of acute stroke. Methods The da tabases including C hina Journa lFul TextD a tabase (C JFD) and W anFang Da tabase from 1991 to 2014 w ere re trieved fo r co lecting the random ized contro led tria ls litera ture tha tmet inclusion criteria. The qua lity of co lected litera ture w as eva lua ted acco rding to the RevM an 5.1 softw are ,and Jadad sco ring method recomm ended by Co-chrane Co labo ra tion w as used in meta ana lysis. Results There w ere 19 litera ture included 1 467 cases,there w ere 755 cases in trea tm ent group(treating w ith XCD and its additional and subtractive recipes com bining w estern medicine) and 712 in contro l group(treating only w ith w estern medicine). The base line da ta w as com parability. Based on Jadad sca le sco ring ,there w ere lo ts of low qua lity litera tures ge tting under 3 sco res ,except 1 high qua lity litera ture ge tting 5 sco res and 5 m iddle qua lity litera tures ge tting 3 sco res. This M e ta ana lysis result show ed tha t trea tm ent groupw as be tter than the contro l groupin im proving to ta l clinica l cura tive effect[ RR = 1.29,95% C I( 1.22,1.37)] ,decreasing N IHSS [WMD= - 4.29,95% C I( - 6.13,- 2.45)] ,reducing TCM syndromeinteg ra ls [WMD= - 3.01,95% C I( - 4.31,- 1.7)] ,reducing stoo l syndromeinteg ra ls [WMD= - 3.63,95% C I( - 4.33,- 2.93)] , i m proving activity of da ily living [WMD= 9.07,95% C I( 5.46,12.67)] ,reducing high plasm a viscosity [WMD= - 0.93,95% C I( -1.4,- 0.46)] ,reducing low plasm a viscosity [WMD= - 1.68,95% C I( - 2.95,- 0.40)] ,reducing fibrinogen [WMD= - 0.5,95% C I ( - 0.96,- 0.04)]. In the treatment group the case mortality [ OR = 0.59,95% C I(0.26,1.34) ,P = 0.21] and CRP[WMD= - 0.66,95% C I ( - 2.08,0.76) ,P = 0.36] had no sta tistica lm eaning. Conclusion The current evidence show ed trea tm ent grouphasd be tter effec-tiveness w hen com pared w ith contro l g roup,but there w as no t enough evidence to suppo rt it could reduce the case m o rta lity. Be-cause of the lim ita tion of litera ture quantity and qua lity,higher qua lity ,rigo rous design ,large sam ple ,m ultiple center and double blind random ized contro led tria ls w ere needed to suppo rt the clinica l effectiveness.
Keywords：acute strokeXinglouChengqidecoctionmeta analysisrandomized controled trials
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1299-1305 )