U linastatin Injected Im proving the Ability ofAng iogenesis in C irculating Endo thelialP rogenitorC els ofAcute Lung Injury and the Effect of PKB/eNOS/NO Pathw ay
Abstract：O bjective To observe the ability of ang iogenesis in acute lung injury circulating endo thelial progenitor cels after uli-nasta tin injected and ang iogenesis of PKB /eNOS /NO pathw ay affected.M ethods The cels in vitro w ere divided into 5 g roups :The contro l group , acute lung injury , ulinastatin treatm ent group , ulinastatin treatm ent + LY294002 group , ulinastatin treatm ent + L NAME groups .Ang iogenicability ,PKB , eNOS pro tein ,NO concentration w ere detected.Results The ability of ang iogenesis in ulinas-ta tin treatm ent group w as higher than that in acute lung injury groups ( P < 0.05) .The PKB , eNOS pro tein expression increased in ulinastatin treatm ent g roup ,and there w as differences betw een ulinastatin treatm ent g roup and acute lung injury groups ( P < 0.05) . NO concentra tion w as increased in ulinastatin treatm ent group , and there w as differences betw een ulinastatin treatm ent g roup and a-cute lung injury g roups ( P < 0.05) .Conclusion U linastatin injection could enhance the ability of ang iogenicability on circulating en-do thelial progenitor cels through PKB / eNOS /NO pathw ay.
Keywords：acute lung injuryendo thelial progenitor ce lsulinastatin injectionang iogenesis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1250-1252 )