Expression of NF κB in Brain Tissue of Rats with Atherosclerotic Ischemic Brain Stroke
Abstract：Objective To research the expressing rule of nuclear factor κB (NF κB)in the brain tissue of rats model with atherosclerot-ic ischemic brain stroke.Methods Forty eight male Wistar rats were divided into control group (n=8),and experiment group (n=40).Rats of the experiment group were designed to rats model with AS,and then were divided into the sham operation group (n=8). 0.5 h model subgroup,6 h model subgroup,12 h model subgroup,24h model subgroup.The expression of NF κB in the brain tissue was detected by immunohistochemical assay.Results The expression of NF κB in each experiment group was higher than the con-trol group (P<0.05),that in continuous ischemia of the model subgroups was higher than sham operation group (P<0.05).The expression of NF κB reached its peak at the 6h.Conclusion NF κB played an important role in the ischemic brain stroke caused by atheroscle-rosis.
Keywords：cerebral ischemic strokeatherosclerosisnuclear factor κBrats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1116-1117 )