Effect of Rosuvastatin on the Concentrations of Serum VCAM 1, ICAM 1 and PAI 1 in Acute Coronary Syndrome

doi:10.3969/j.issn.16721349.2014.09.009

Abstract：Objective To explorer the effect of different doses of rosuvastatin on serum concentrations of vascular cell adhesion molecule l (VCAM 1),intercellular adhesion molecule 1(ICAM 1),and plasminogen activator inhibitor 1 (PAI 1)in the pa-tients with acute coronary syndrome (ACS).Methods A total of 236 patients with acute coronary syndrome were randomly divided into A group (128 patients were administrated to rosuvastain 10 mg per day)and B group (128 patients were administrated to rosuv-astain 20 mg per day).Another 50 age matched healthy subjects who were confirmed no coronary artery stenosis by coronary angi-ography were enrolled as control group.Serum samples of the patients in both A and B group were collected in order to detect the level of VCAM 1,ICAM 1,and PAI 1 before the patients accept rosuvastain and 1 and 2 weeks after the treatment.The level of VCAM 1, ICAM 1 ,and PAI 1 were measured by Enzyme Linked Immunosorbent Assay.Results Compared with the control group,the con-centrations of serum VCAM 1,ICAM 1,and PAI 1 were significantly increased in patients with ACS (P<0.05).After 1 and 2 weeks of the treatment,the concentrations of serum VCAM 1,ICAM 1,PAI 1 were decreased both in A and B group (P<0.05). Whereas in the B group,the concentrations of serum VCAM 1 ,ICAM 1 ,and PAI 1 were lower than that in the A group both 1 and 2 weeks after the treatment (P<0.05).Conclusion Significant decreases of VCAM 1,ICAM 1 and PAI 1 in ACS patients were observed at both 1 and 2 weeks after treatment with rosuvastatin,and significantly greater reduction were observed with the in-creasing dose of rosuvastatin.