Relationship between Hypertensive Carotid Atherosclerosis and Matrix Metalloproteinase 3 Genotype
Xu Chunhua
Abstract：Objective To analyze and evaluate the correlation of hypertension carotid atherosclerosis and matrix metalloproteinase 3 (MMP 3)genotype.Methods The MMP 3 gene promoter had three kinds of genotypes in the 1171 locus:6A/6A,5A/6A and 5A/5A.The distribution of three kinds of genotypes were studied in 108 hypertension patients (observation group),and 102 healthy controls (control group).The carotid ultrasonography were examined in 6 9 cases in observation group and 3 1 cases in control group and intima media thickness (IMT)were compared.Results In the observation group,genotype 6A/6A (65.7%)and the frequency of 6A allele (82.4%)was higher than that (53.8%)genotype and allele frequency (75.9%)in the control group,but the distribution difference was not statistically significant(compared with genotype P=0.092,allele P=0.118).The observation group patients with the 6A/6A genotype in the starting position,and expanded rapidly before parts of IMT were significantly higher than those in the con-trol group (P<0.05).Conclusion In patients with hypertension carotid intima media thickness was affected by many risk factors. Iintima media thickness was increased in hypertensive patients with 6A/6A genotype.
Keywords：hypertensioncarotid atherosclerosismatrix metalloproteinase-3genotypeintima media thickness
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1047-1049 )