Effects of Paeonol on CRP in Rats with Atherosclerosis
Abstract：Objective To investigate the effects of paeonol on C reactive protein (CRP)in rats with atherosclerosis (AS).Meth-ods Rats model with AS was established by administration of high fat diet and vitamin D3 (i.p.).Rats were divided into 4 groups (n=8 each group)at random,namely normal group(n=8),model group(n=8),positive group(simvastatin 10 mg/kg,n=8),and paeonol group (paeonol 20 mg/kg,n=8).After 4 weeks of oral treatment,the sera of all rats were collected to determine the levels of CRP by ELISA,and the aortic pathologic changes were observed and graded under microscope.Results Administration of paeonol (20 mg/kg)improved the severity of aortic pathology in AS rats.The pathologic grade in paeonol group showed a significant differ-ence compared with that of model group (P<0.01).Paeonol markedly decreased the serum CRP level (6.0 ng/L±1.5 ng/L)in rats with AS,which showed significant differences compared to that of model group (P<0.01).Conclusion Paeonol showed certain ther-apeutic effect on AS rats,and the mechanisms might be involved in inhibiting the expression of CRP.
Keywords：atherosclerosispaeonolC reactive protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 991-992 )