Naomai Jiejing Decoction for Prevention and Treatment of Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage
Abstract：Objective To investigate the efficacy,safety and the possible mechanism of Naomai Jiejing decoction (NJD)for treat-ment of delayed cerebral ischemia (DCI)in patients with aneurysmal subarachnoid hemorrhage.Methods Sixty patients were ran-domly divided into two groups:Treatment group (n=30)treated by NJD 1 and western medicine,and control group (n=30)treated by NJD 2 and western medicine.The incidence of DCI,National Institutes of Health Stroke Scale (NIHSS)score,the number of micro thrombosis,the difference of the TCD middle cerebral artery mean flow velocity,and levels of PAF and ADP were observed at 3 d,7 d,14 d.Results The incidence of DCI,NIHSS score,and the number of micro thrombi in treatment group was significantly lower than that in control group at 7 d,and 14 d (P<0.05).The average middle cerebral artery blood flow velocity was lower than that in control group at 7 d (P<0.05),there was no significant difference at 14 d (P>0.05).Plasma PAF and ADP levels were lower than that in control group (P<0.05)at 7 d and 14 d.Mortality rate (2 cases in the treatment group and 3 cases in control group)was not statistically significant in two treatment groups (P>0.05).Conclusion NJD could suppress PAF and ADP activity.It could reduce the formation of micro thrombosis,incidence of DCI and the neurological deficit,and improve prognosis in aSAH patients.
Keywords：subarachnoid hemorrhagecerebral ischemiaintracranial aneurysmNaomai Jiejing decoction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 920-922 )