Effects of Fasudil Hydrochloride on Contractility and Migration of Pulmonary Artery Smooth Muscle Cells in Rats
Abstract：Objectives To investigate the effects of fasudil on the contractility and migration of rat pulmonary artery smooth mus-cle cells (PASMCs).Methods PASMCs were incubated or not (controls)with different concentrations(10μmol/L,30μmol/L,50μmol/L)of fasudil.The contractility and migration of PASMCs were investigated by collagen gel contraction assay and boyden cham-ber assay,respectively.Results Fasudil effectively inhibited the contractility and migration of PASMCs (P<0.01),in a dose de-pendent manner.Conclusion Fasudil effectively inhibited the contractility and migration of PASMCs,which might serve as an impor-tant mechanism of its anti pulmonary arterial hypertension effects.
Keywords：Pulmonary hypertension pulmonary smooth musclefasudilcell contractioncell migration
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 866-867 )