Prognostic Value of N pro B type Natriuretic Peptide Combined with TIMI Risk Score for ST Segment Elevation Myocardial Infarction
Li Xuemei
Abstract：Objective To investigate the predicting value of major adverse cardiovascular events (MACE)with scoring system of thrombolysis in myocardial infarction (TIMI)risk score and N terminal pro B type natriuretic peptide (NT proBNP)in ST segment elevation myocardial infarction (STEMI).Methods The serum level of NT proBNP and TIMI risk score in 304 STEMI patients were measured in a retrospective study.The receiver operating characteristic curve (ROC)and Logistic regression analysis were used to evaluate prognostic contribution of NT proBNP and TIMI risk score,and propose an optimal cut off of NT proBNP.TI-MI risk score modified by NT proBNP was created.The accuracy of this new score was compared with the usual TIMI risk score by comparing the area under the curve (AUC)of the 2 scores.Results The results by ROC showed that:NT proBNP (AUC 0.732, 95%CI 0.670 to 0.794,P<0.01),predictive optimal cutoff of the incidence of MACE was 741ug/L.TIMI risk score was AUC 0. 792(95%CI 0.735 to 0.848,P<0.01).Addition of NT proBNP to the TIMI risk score could improve its prognostic value (AUC 0.836,95%CI 0.786 to 0.885,P<0.01),the difference was statistically significant by paired t test(Z=15.977,P<0.01).Conclusion NT proBNP could add the prognostic value of TIMI risk score for MACE rate of STEMI patients both hospitalization and follow up.
Keywords：N terminal pro B type natriuretic peptideTIMI risk scoreST segment elevation myocardial infarctionprog nosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 807-809 )