Influence of Qili Qiangxin Capsules Combined with Carvedilol on the Levels of Blood NF κB and iNOS in Congestive Heart Failure
Abstract：Objective To observe the influence of carvedilol combined with Qili Qiangxin capsules(QQC)on the levels of blood nuclear factor kappa B (NF κB),inducible nitric oxide synthase (iNOS)in patients with early congestive heart failure(CHF). Methods One hundred and twenty patients with early CHF were randomly divided into routine treatment group,carvedilol group,and carvedilol combined with QQC treatment groups,and 40 cases were included in each group.After medication for 12 weeks,the blood levels of iNOS and NF κB were detected with enzyme linked immunosorbent assay and fluorescent quantitation PCR,respectively. The left ventricular ej ection fraction (LVEF)and walking distance in 6 minutes were detected at the same time.Results After 1 2 weeks drug therapy,the blood levels of NF κB and iNOS were decreased significantly (P<0.01),and walking distance in 6 minutes and LVEF were increased(P<0.05)in carvedilol group and carvedilol combined with QQC groups compared with that in routine treat-ment group.The blood levels of NF κB and iNOS were decreased (P<0.05)in carvedilol group compared with carvedilol combined with QQC group,while there were no significantly differences of walking distance in 6 minutes and LVEF between the two groups. Conclusion QQC combined with carvedilol could improve the exercise tolerance and improve cardiac function of early CHF patients and it might due to its inhibiting effects on the expression of inflammation factors.
Keywords：congestive heart failurecarvedilolQili Qiangxin capsulesnuclear factor kappa Binducible nitric oxide synthase
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 787-789 )