The Regulation of Rhynchophylline on the Expression Levels of Dopamine,Superoxide Dismutase and Malondialdehyde in Rats with Parkinson Disease
Wang Xiangming
Lu Xuesheng
Abstract：Objective To study the regulation of rhynchophylline on the expression levels of dopamine(DA),superoxide dismutase (SOD)and malondialdehyde (MDA)in rats with Parkinson disease (PD).Methods First to extracted rhynchophylline from tradi-tional Chinese medicine uncaria.The second part is to injury PD rat model by Brain positioning injection of 6 OHDA,compare and analyze normal group,model group and rhynchophylline group.Determine DA,SOD in serum and MDA activity in rats’brains by bio-chemical method,and analyze the impact of rhynchophylline on its activity.Results After 30 days drug administration,DA density level of rhynchophylline group was significantly higher than that of model group (P<0.01).At the SOD level,rhynchophylline group was significantly higher than that in model group (P<0.05).Meanwhile the content of MDA compared with the normal group,rhyn-chophylline group and normal group ware close and significantly lower than that of model group (P<0.05).Conclusion Rhyncho-phylline could adj ust SOD,DA and MDA in brains in rats with Parkinson disease (PD).It shows a value of development in Parkinson disease treatment or prevention of drug.
Keywords：Parkinson diseaserhynchophyllinedopaminesuperoxide dismutasemalondialdehyde
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 730-731 )