Influence of Jiawei Danshen Decoction on Mobilization of Bone Marrow Stem Cells in Rats with Myocardial Ischemia Reperfusion Injury
Abstract：Objective To study the effect of Jiawei Danshen decoction (JDD)on the expression of CD34+ protein and heart func-tion of rats with myocardial ischemia reperfusion injury (IRI),and therefore to investigate the potential mechanisms of JDD on myo-cardial (IRI)and bone marrow stem cells(BMSCs)mobilizating.Methods One hundred and twenty rats were randomly divided into 7 d,14 d and 28 d duration after making model of IRI.Forty rats were randomly divided into 5 groups with 8 rats each group in period of time:Sham operation group(group A),IRI group(group B),rhEPO group(group C),JDD group(group D),joint group(group E). The expression of myocardial cells CD34+ protein was observed by immunohistochemistry.The heart function was observed.Results And rhEPO mobilization and JDD group Compared with group C and group D,the heart function was significantly improved and the expression of CD34+ protein was increased obviously in group E(P<0.05 or P<0.01).Conclusion JJD of joint mobilization of bone marrow stem cells can improve the myocardial IRI rat stem cell mobilization effect,can increase heart function.The results might display the potential mechanisms of JJD on myocardial IRI.
Keywords：Jiawei Danshen decoctionmyocardial ischemia reperfusion injurybone marrow stem cells
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 723-725 )