Clinical Study with Combination of QiShen YiQi Dripping Pill with Trimetazidine in Patients in Heart Failure with Preserved Ejection Fraction
Li Xin
Abstract：Objective To investigate the effects of Qishen Yiqi dripping pills(QYDP)and trimetazidine for treatment of heart fail-ure with preserved ejection fraction(HF PEF).Methods One hundred and twenty patients with HF PEF were randomly divided in-to three groups:Control group (n=40)treated by routine treatment of heart failure,QYDP group(n=40)treated by routine treat-ment plus QYDP,combination treatment group(n=40)treated by routine treatment plus QYDP and trimetazidine.The New York Heart Association (NYHA)functional class and six minute walking test (6 min WT)and B type natriuretic peptide (BNP)were recorded,ratio of maximal velocity of bicuspid blood flow in the early(E)and advanced(A)stages of left ventricle diastole(E/A)and early diastolic peak velocity/tissue early distolic velocity ratio (E/e’)were detected by echocardiogram before and after treatment.Re-sults The effective rate and the total effective rate in QYDP group and combination treatment group were higher than those in con-trol group,while those in combination treatment group were better than QYDP group (P<0.05).E/A,E/e’in QYDP group and combination treatment group after treatment improved sig nificantly than that in control group,6 min WT distance was extended(P<0.05,P<0.01).Compared with QYDP group,indicator of combination treatment group improved more significantly after the treat-ment (P<0.05).Conclusion QYDP and trimentazidine on the basis of routine treatment of heart failure can improve cardiac function in patients with HF PEF.
Keywords：heart failurepreserved ej ection fractionQishen Yiqi dripping pillstrimetazidine
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 557-559 )