Blood Stasis Syndrome Identification Modes of Coronary Heart Disease Based on Metabonomics
Abstract：Objective To screen the characteristic metabolites related to the blood stasis syndrome to establish blood stasis syn-drome identification modes in the metabolic level.Methods Plasma samples of 45 patients with coronary heart disease (CHD)and 15 healthy subj ects were detected with hydrogen nuclear magnetic resonance.The plasma endogenous metabolites were identified and screened from micro molecules to macro molecules by PLS DA,VIP and method t tests/non parametric test.Characteristic me-tabolites related to blood stasis syndrome were screened.Results Thirty nine endogenous metabolites were detected in CHD pa-tients and healthy control group.PLS DA integral matrix graphs of CPMG and LED showed:Distribution region of blood stasis and non blood stasis patients could be completely separated along the t (1)axis direction.The separated modes had a high fitting degree. Characteristic metabolites screening results showed that characteristic metabolites of blood stasis were valine and acetone.Conclusion The abnormal metabolism in CHD blood stasis patients was amino acid and lipid metabolism.These 2 metabolic biomarkers basically could realize the effective recognition of blood stasis syndrome.
Keywords：metabonomicscoronary heart diseaseblood stasis syndromeidentification modes
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 513-516 )