Effect of Xinfukang Oral Liquid on the Expression of mit CK mRNA and Protein in Rats with Heart Failure after Myocardial Infarction
Abstract：Objective To study the effect of Xinfukang oral liquid(XOL)on the expression of mitochondrialcreatine kinase(mit CK) mRNA and protein in rats with heart failure after myocardial infarction.Methods The rat models of heart failure after myocardial infarction were created by ligating their left anterior descending coronary arteries.after 24 hours of creating models,rats in drug groups were fed on XOL and captopril through gastotube for 6 weeks,while captopril group was served as control.The expression of mit CK mRNA and protein around infarction area were observed.Results Compared with mode group,the expression of mit CK mRNA and protein in captopril group and XOL group were increased at 6th weekend (P <0.01).Compared with captopril group,the expression of mit CK mRNA in XOL group was decreased at 6th weekend (P <0.05).While there was no significant difference in mit CK protein expression between captopril group and XOL group at 6th weekend (P >0.05).Conclusion XOL can effectively in-crease the expression level of mit CK mRNA,as well as the protein content of mit CK of rats with heart failure after myocardial in-farction,and thus help to improve heart failure myocardial energy shuttle and remodel the process of myocardial energy metabolism function.
Keywords：heart failureXinfukang oral liquidenergy metabolismmit CKmyocardial infarction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 461-463 )