Influence of Supplementing Qi and Activating Blood Circulation Compound Formula on PAI-1 and t-PA

doi:10.3969/j.issn.1672-1349.2009.08.027

Abstract：Objective To observe the influence of "supplementing Qi and activating Blood circulation" compound on PAI-1,t-PA and ultrastructure in rabbit with arthrosclerosis.Methods Forty New Zealand male rabbits were divided into 5 groups in random:Normal group (n=8),model group (n=8),"supplementing Qi and activating Blood circulation" group (n=8),and traditional Chinese medicine group (n=8),western medicine control group (Simvastatin control group n=8).The models were established by injuring carotid arteries.In 4 weeks,normal group was fed with normal forage and the others were fed with high fat forage.At the forth weekend,"supplementing Qi and activating Blood circulation" compound,Xuezhikang capsule and simvastatin were respectively given in the next 4 weeks by continuous administration.The PAI-1 and t-PA were detected before and after therapy.At the 8th weekend,rabbits were sacrificed and the left and right common carotid artery were taken and observed by transmission electron microscope.Results The PAI-1 in model group was increased gradually and t-PA was increased slightly.Comparing the "supplementing Qi and activating Blood circulation" therapy group and the model group,PAI-1 was descended obviously with significant differences(P<0.01) and t-PA was elevated obviously with significant differences (P<0.01).Among every administration group,PAI-1 and t-PA had no difference (P>0.05).It was confirmed in electron microscope that the "supplementing Qi and activating Blood circulation" compound could improve the ultrastructue of arteria carotis interna.Conclusion The "supplementing Qi and activating Blood circulation" compound could promote the secretion of plasminogen activator and reduce the secretion of the plasminogen activator inhibitor.It could enhance fibrinolytic activity and reduce arthrosclerosis.