Effect of Ruanmailing on Myocardial Remodeling in Spontaneously Hypertensive Rats
Abstract：Objective To observe the effects of Ruanmailing (RML) on the remodeling of myocardium in spontaneously hypertensive rats (SHR).Methods Thirty-six male SHRs were randomized into 4 groups:High-dose RML group [RH:3 mL/(kg·d)],low-dose RML group [RL:1 mL/(kg·d)],untreated control (SHR),losartan positive control [(Los:10 mg/(kg·d)].Systolic blood pressure was examined by the tail-cuff at 12 weeks.The ratio of wet weight of left ventricle to body weight (LVM/BW) was assessed.Myocardial collagen fibers in the sections were observed under light microscope.Results After 12 weeks treatment,systolic blood pressure in both RML groups was markedly lower than that in SHR (P<0.01).The perivascular myocardial collagen volume fraction was significantly reduced in treatment group with RH (P<0.01),while no significant difference in RL was found.The middle-level of myocardial collagen volume fraction was markedly decreased in RML groups (P<0.01).After 12 weeks treatment with RH and RL,the artery of myocardial collagen volume fraction in both groups was significantly decreased than that in SHR(P<0.01).Conclusion RML might prevent the development of hypertension in SHR.RML might inhibit accumulation of cardiac collagen fibers
Keywords：hypertensionspontaneously hypertensive ratsRuanmailingmyocardial fibrosis
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 932-933 )