Effect of Brain Oxidative Stress on Heart Function of Angina
Abstract：Objective To investigate the effect of brain oxidative stress on heart function of angina.Methods Angina or sham surgery (SHAM) in adult male Sprage-Dawley rats were reduced by left anterior descending coronary artery ligation.Intracerebroventricular (ICV) cannulae was implanted and treated with APO (60 μg/3 min).NADPH oxidase inhibitor,or vehicle (VEH) was used for 10 minutes.At the end of the study,left ventricular (LV) function was measured by hemodynamics and rats were sacrificed.Brain tissue and plasma were collected for measurement of the expression of gp91 phox using immunohistochemistry.Heart and lung tissues were also harvested.Body weight (BW),wet lung weight and right ventricular (RV) weight were weighted.Results The expression of gp91phox in the paraventricular nucleus (PVN) of hypothalamus in rats with angina was significantly increased compared with that in sham rats.The expression of gp91phox in the PVN was attenuated by ICV treatment with APO compared with that in angina rats by VEH-treated.ICV treatment with APO also reduced lung/BW radio and RV/BW radio,decreased LV end-diastolic pressure with increased maximum rate of left ventricular pressure rise (+dp/dtmax) and peak rate of left ventricular pressure fall (-dp/dtmax).Conclusion The findings suggested that the brain oxidative stress could increase inhibitor of brain NADPH oxidase to reduce the levels of oxidative stress which might attenuate cardiac dysfunction.
Keywords：oxidative stressanginaparaventricular nucleus of hypothalamus
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 928-930 )