Improvement of Aspirin Resistance in Chronic Stable Angina by Talcom
Abstract：Objective To evaluate therapeutic value of Talcom on aspirin resistance in chronic stable angina.Methods Six hundreds and ten patient (pts) with chronic stable angina was divided into aspirin sensitive group (AS) and aspirin resistant group (AR) based on platelet aggregation fraction.One hundred and thirty-eight pts in AR group were sub-divided into AR-A group,Talcom group,and combined (AR-C) group randomly.Forty pts of in AS group were as control group.Pts were followed-up for one year after medication to observe platelet aggregation fraction,incidence of ischemic cardiovascular or cerebrovascular disease,and incidence of hemorrhagic event.Results Platelet aggregation fraction in Talcom group were reduced significantly(P<0.01) without increasing incidence of hemorrhagic event (P>0.05).Frequency of ischemic ST segment variation,persistence time,overall load of myocardial ischemia in Talcom group and AR-C group were less than that in AR-A group (P<0.05 or P<0.01).Conclusion Talcom with aspirin was safe,and could elevate clinical therapeutic effect in pts with chronic stable angina.
Keywords：chronic stable anginaTalcomAspirin resistance
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 892-894 )