The Effect of Xuefuzhuyu Decoction on the Protein Expression of c - fos and c - jun in Atherosclerosis Vascular Smooth Muscle Cells
Abstract：Objective To study the effect of Xuefuzhuyu decoction and its disassembled prescription on the protein expression of c- fos and c -jun in atherosclerosis vascular smooth muscle cells. Methods The rabbit models with atherosclerosis were established by high cholesterol diet. The protein expression of c - fos and c -jun in aortic artery were detected by immunohistochemistry assays. Results The protein expression of c - fos and c -jun in model group were remarkably increased(P<0.01). Compared with the modcl group, the expression of c - fos in Xuefuzhuyu decoction group and Taohongswu decoction group were decreased(P<0.01). The ex-pression of c -jun in Xuefuzhuyu decoction group, Taohongswu decoction group and Sinisan decoction group were decreased(P<0.05). Conclusion Xuefuzhuyu decoction and its disassembled prescription could decrease the expression of c - los and c -jun in atheroscle-rosis vascular smooth muscle cells. It might be one of the mechanisms of anti - proliferation in atherosclerosis vascular smooth muscle cells.
Keywords：Xuefuzhuyu decoctiondisassembled prescriptionproliferationimmunohistochemistry
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 795-797 )