Clinical Significance of Brain Natriuretic Peptide and Doppler Ultrasound in Diastolic Heart Failure
Abstract：Objective To evaluate the cardiac function in patients (pts) with diastolic heart failure by plasma brain natriuretic peptide(BNP)with Doppler echocardiography parameters. Methods A total of 85 patients(pts) with diastolic heart failure (31 cases with NYHA class Ⅱ,36 cases with NYHA class Ⅲ and 18 cases with NYHA class Ⅳ) were enrolled. Thirty individuals were enrolled as healthy control group. The plasma BNP was measured. Doppler ultrasound with tissue Doppler imaging(TDI)was performed to deter-mine left ventricular structure,left ventricular diastolic function and left ventricular end diastolic pressure. Results The level of plas-ma BNP was increased in pts with diastolic heart failure as compared to healthy control group(P<0.001). The level of plasma BNP was gradually increased with the severity of diastolic heart failure(P<0.001). Compared with healthy control group, left atrium (LA),interventricular septum(IVS),left ventricle posterior wall(LVPW)and E/Em ratio increased and E/A ratio decreased in dias-tolic heart failure group(P<0.001). The level of plasma BNP had negative correlation wilh E/A ratio (r= -0.634, P<0.01) and positive correlation with E/Em (r=0.728,P<0.01). Conclusion Plasma BNP and Doppler echocardiography parameter were the simple and accurate to evaluate the cardiac function in pts with diastolic heart failure.
Keywords：diastolic heart failurebrain natriuretic peptideDoppler echocardiography
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 768-769 )