Research Progress on Yueju Pills in the Treatment of Vascular Dementia Based on the Theory of Soothing the Liver and Regulating the Spleen
LUO Lin
HU Nan
FU Yeping
MENG Xinyan
Abstract：Vascular dementia(VaD)is widely regarded as the second most common type of dementia after Alzheimer's disease.The aging population and increasing life expectancy have significantly contributed to its rising incidence.Patients with VaD may exhibit behavioral changes,declines in attention and memory,and other cognitive deficits.Without timely and effective intervention,the progression of the disease can severely impair neurological functions,leading to motor,sensory,and perceptual disturbances,which significantly reduce the quality of life.Despite its high incidence and substantial social impact,current treatment options for VaD remain rather limited,primarily focusing on symptom control and management.Conventional Western medical treatments for VaD mainly include cholinesterase inhibitors,anticoagulants,lipid-lowering agents,and vasodilators.However,these drugs often fail to achieve satisfactory long-term outcomes and may even cause significant adverse effects such as dizziness,vomiting,and agitation with prolonged use.Based on its clinical manifestations,VaD can be categorized under the concept of"dementia"in traditional Chinese medicine(TCM).Both classical TCM theories and previous studies have shown that TCM interventions based on the"soothing the liver and regulating the spleen"theory demonstrate favorable clinical efficacy in preventing and treating VaD.Modern clinical research has also confirmed that Yueju Pills can effectively treat mild to moderate VaD,significantly improving patients' cognitive function and daily living abilities.Thus,the clinical effectiveness of TCM in managing VaD has been fully validated through long-term practice,with additional advantages such as minimal side effects,good patient tolerance,and high acceptability.This review summarizes the efficacy of Yueju Pills in preventing and treating VaD based on the"soothing the liver and regulating the spleen"theory,aiming to provide new directions and insights for further research into TCM approaches for VaD,as well as to offer literature references and evidence for the clinical application of TCM in VaD management.
Keywords：vascular dementiaYueju Pillstraditional Chinese medicineresearch progress
Publication Date：2026-05-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：7( 90-96 )