Research Progress on the Regulation of Mitochondrial Autophagy and Oxidative Stress by Active Ingredients in Traditional Chinese Medicine for the Treatment of Depression
TANG Haixiu
GAO Yuguang
LIANG Ke
ZHAO Shuai
HE Qianchao
Abstract：Depression is an increasingly serious mental health problem worldwide,with a complex pathogenesis involving multiple factors such as neurotransmitter imbalance,neuroinflammation,abnormal neurotrophic factors,and mitochondrial dysfunction.In recent years,the active ingredients of traditional Chinese medicine have shown potential application value in the treatment of depression due to their multi-target and multi pathway effects.Mitochondrial autophagy,as a key mechanism for clearing damaged mitochondria within cells,plays an important role in maintaining neuronal health.Research has shown that patients with depression often suffer from mitochondrial dysfunction,and active ingredients in traditional Chinese medicine can improve such disorders by regulating mitochondrial autophagy,thereby alleviating depressive symptoms.In addition,oxidative stress also plays an important role in the occurrence and development of depression;The active ingredients of traditional Chinese medicine reduce the generation of reactive oxygen species through antioxidant effects,protecting nerve cells from oxidative damage.Therefore,in-depth exploration of the mechanism by which active ingredients in traditional Chinese medicine regulate mitochondrial autophagy and oxidative stress is of great significance for the development of novel treatment strategies for depression.
Keywords：depressionactive ingredients of traditional Chinese medicinemitochondrial autophagyoxidative stress
Publication Date：2026-01-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：8( 78-85 )