Discussion on the Mechanism of Ferroptosis to Promote Atherosclerosis and Related Research Progress of Traditional Chinese Medicine Intervention
LI Zhiyang
WANG Shuai
Abstract：Ferroptosis is a new type of cell death,which is closely related to lipid peroxidation(LPO)and iron overload,and its mechanism is mainly related to iron metabolism disorders,decreased activity of System Xc-/GSH/GPX4 antioxidant system,abnormal fatty acid regulation,and other pathways.Atherosclerosis(AS)is a chronic inflammatory disease characterized by lipid metabolism disorders,which can lead to severe stenosis in the lumen of the body's arteries with the occurrence and progression of AS,which promotes the occurrence of cardiovascular and cerebrovascular diseases and threatens life.It has been confirmed that ferroptosis is involved in multiple pathological processes of AS,including endothelial cell damage,macrophage inflammatory response,foam cell formation,and vascular smooth muscle cell proliferation and migration,and may become a new target for AS research.At the same time,many studies have shown that ferroptosis can be regulated by multiple mechanisms,pathways,and targets in traditional Chinese medicine,so as to achieve the purpose of controlling and delaying the development of AS and improving symptoms.This article reviews the mechanism of ferroptosis in AS and the research progress of related traditional Chinese medicine interventions,aiming to take ferroptosis as a starting point to carry out new discussions on the prevention and treatment of As by traditional Chinese medicine and to provide new ideas and solutions.
Keywords：atherosclerosisferroptosisoxidative stressmedicinal herb
Publication Date：2025-11-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：6( 80-85 )