Study on Preparation Extraction Process of Taohong Siwu Decoction
CHEN Jianshuang
ZHAO Lulu
YANG Yanling
WANG Yi
ZHENG Shunliang
WU Yongsheng
Abstract：Objective To optimize the extraction process of Taohong Siwu Decoction compound preparation,ensuring consistency in composition and efficacy with traditional decoction.Methods By establishing HPLC characteristic spectra,the content and extract amount of five indicator components(amygdalin,paeoniflorin,hydroxysafflor yellow A,ferulic acid,and ligustilide)were determined,and the extraction effects of eight different extraction processes were compared.The 8 processes include:traditional decoction method(process 1),distillation of volatile oil and merging of residual liquid(process 2),secondary reflux method(process 3),traditional decoction method after volatile oil extraction(process 4),direct steam heating extraction method(process 5),70%ethanol reflux method(process 6),50%ethanol ultrasonic method(process 7),and 90%ethanol water extraction method(process 8).Results Taking process one as a reference,the similarity of feature maps between process two and process four is higher than 0.95,and there is no significant difference in the content and output of the five indicators in statistics;The similarity of the feature map of process three is 0.973,but the amount of paste produced significantly increases and there is a phenomenon of material swelling;The similarity between the feature maps of Process 5 and Process 8 is about 0.7.The content and paste output of the four indicator components in Process 5 have decreased,while the five indicator components in Process 8 have slightly increased,which may be related to the duration of heating;The similarity between the feature maps of process six and seven is relatively low,and the content and output of the five indicator components are significantly reduced.Conclusion Process four performs the best in retaining the content of volatile and indicator components,and is considered the optimal extraction process.
Keywords：Taohong Siwu Decoctionclassical prescriptionbaseline sampleextraction processsolid state preparation
Publication Date：2025-11-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：6( 17-22 )