Research Progress on Inflammatory Responses Associated with Bronchopulmonary Dysplasia
SONG Yue
MEI Mei
YANG Song
NIE Jing
YANG Shuhe
Abstract：Bronchopulmonary dysplasia(BPD)is one of the most common chronic lung diseases in premature infants,with an increasing incidence.However,its pathogenesis and effective prevention and treatment measures still require further research.Immature lung development,inflammatory injury,and abnormal repair after injury are key links in the occurrence and development of BPD.Recent studies have shown that inflammatory response plays a crucial role in the occurrence and development of BPD,involving interactions among various cytokines,signaling pathways,and microbial communities.This article reviews the definition and pathogenesis of BPD,related inflammatory responses,and anti-inflammatory treatment from three aspects.The inflammatory mechanisms of BPD are complex and diverse,mainly including:infection-activated inflammatory response,mechanical ventilation-induced lung injury exacerbating local inflammation,oxidative stress triggered by hyperoxia exposure promoting inflammatory cascade,microecological imbalance affecting immune regulation through the"gut-lung axis",and genetic factors.In terms of treatment strategies,anti-inflammatory intervention has become a research hotspot,with glucocorticoids,macrolide antibiotics,traditional Chinese medicine,probiotics,optimized mechanical ventilation modes and stem cell therapy providing new ideas for the treatment of BPD.Systematically reviewing the pathogenesis and treatment progress of BPD-related inflammatory responses aims to provide theoretical basis for the prevention and treatment of lung diseases.
Keywords：bronchopulmonary dysplasiainflammationmechanismtreatment
Publication Date：2025-08-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：7( 85-91 )