Study on the Homologous Relationship Between"Innate Essence"and Bone Marrow Mesenchymal Stem Cells in Chinese Medicine
GU Haili
NA Junfu
YU Dongdong
Abstract：In the theory of traditional Chinese medicine,"innate essence"is the material basis for the occurrence,development and repair of the human body,and the basis for maintaining life activities.Bone marrow mesenchymal stem cells(BMMSCs)are a subgroup of stem cells in the bone marrow with multiple differentiation potential.Although the two theories are different,they both explain the basic life laws of human growth,development and reproduction,suggesting that"congenital essence"and BMMSCs are theoretically homologous,highly similar in physiological function,similar in pathophysiological transformation process,and accompanied by aging mechanism,which can be used as the entry point for TCM intervention in BMMSCs differentiation and treatment of osteoporosis.At the same time,based on the homologous relationship between the two,the study of"tonifying kidney and filling essence"intervention in bone differentiation of BMMSCs to prevent osteoporosis was discussed,and the clinical research mechanism of preventing postmenopausal osteoporosis by tonifying kidney and filling essence was proposed based on the"theory of the mutual use of Yin and Yang".Based on the review of relevant studies,this paper reviewed the progress of research on the homologous relationship between congenital essence and BMMSCs,and further explored the relevant mechanism of"supplementing kidney essence"in the prevention and treatment of postmenopausal osteoporosis to improve its clinical application value and provide new ideas for the study of traditional Chinese medicine in the prevention and treatment of postmenopausal osteoporosis.
Keywords：innate essencebone marrow mesenchymal stem cellsaging mechanisms
Publication Date：2025-08-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：5( 29-33 )