Discussion on"Treating the Same Disease with Different Methods"—Mechanism of Erchen Decoction(二陈汤)and Shenling Baizhu Powder(参苓白术散)in the Treatment of Obese Type 2 Diabetes from the Intestinal Flora
ZHANG Lijing
ZHAO Tian
HANG Tianyi
ZHOU Wen
ZHAN Libin
Abstract：Objective To observe the effect of Erchen Decoction and Shenling Baizhu Powder on intestinal flora of obese type 2 diabetes rats,and explore the scientific connotation of"treating the same disease differently".Methods 5-week-old male ZDF rats were randomly divided into a model group,a Erchen Decoction group,and a Shenling Baizhu Powder group,with the same litter lean type as the control group.The Erchen Decoction group and the Shenling Baizhu Powder group were given daily gavage interventions of 4.58 g/kg and 24 g/kg corresponding formulas,respectively.The remaining groups were given equal amounts of ultrapure water for a total of 4 weeks.Perform 16S rRNA sequencing and analysis on the contents of the cecum in rats.Results Erchen Decoction and Shenling Baizhu Powder can jointly increase the bacteria genera including Lactobacillus,Blautia and Dorea.The difference in their regulation is that Erchen Decoction can reduce the abundance of 7 bacteria genera including Holdemania,Ruminococcus and Atopostipes,and increase the abundance of 20 bacteria genera including Blautia,Clostridium and Lactobacillus,while Shenling Baizhu Powder can reduce the abundance of 7 bacteria genera including Allobaculum,Eubacterium and Coprococcus to improve the disorder of glucose and lipid metabolism and delay the occurrence of obesity type 2 diabetes development.Their functional enrichment displays obvious similarities and differences.Conclusion Erchen Decoction and Shenling Baizhu Powder can improve obesity type 2 diabetes by regulating the intestinal flora of ZDF rats.The difference in biological targets reflects the difference in the efficacy of traditional Chinese medicine between the two prescriptions,which makes a preliminary exploration of the biological basis of the traditional Chinese medicine theory of"treating the same disease differently".
Keywords：obesity type 2 diabetesErchen Decoction(二陈汤)Shenling Baizhu Powder(参苓白术散)gut microbiota
Publication Date：2024-11-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：9( 17-25 )