Analysis of the Predictive Value of Serum PCT,BNP and hs-CRP for Acute Exacerbations in COPD Patients with Respiratory Failure

ZHANG Shibao

doi:10.14033/j.cnki.cfmr.2026.06.005

Abstract：Objective:To investigate the predictive role of serum procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),and B-type natriuretic peptide(BNP)in acute exacerbations of chronic obstructive pulmonary disease(COPD)complicated by respiratory failure(RF).Method:A retrospective analysis of clinical data from 100 patients with COPD complicated by RF admitted to Jiangning Hospital of Traditional Chinese Medicine in Nanjing from January 2021 to June 2025 was conducted.Patients were categorized based on acute exacerbation status into an acute exacerbation group(n=36)and a non-acute exacerbation group(n=64),and further classified by prognosis into a favorable prognosis group(n=73)and an unfavorable prognosis group(n=27).The levels of BNP,PCT,and hs-CRP were compared to assess their predictive value for acute exacerbations and their association with poor prognosis.Result:The levels of PCT,BNP,and hs-CRP were higher in the acute exacerbation group than in the non-acute exacerbation group,with statistically significant differences(P<0.05).PCT,BNP,and hs-CRP were risk factors for acute exacerbations in COPD patients with RF(OR>1).The AUC values for predicting acute exacerbations using these three markers individually and in combination were 0.738,0.768,0.666,and 0.893,respectively.Patients in the poor prognosis group exhibited significantly higher levels of PCT,BNP,and hs-CRP compared to those in the favorable prognosis group,indicating a positive correlation with poor clinical outcomes,and the differences were statistically significant(P<0.05).Conclusion:Serum PCT,BNP,and hs-CRP,whether measured individually or in combination,demonstrate high predictive value for acute exacerbations in COPD patients with risk factors,and the levels of these three markers are positively correlated with poor patient outcomes.