Clinical Efficacy Analysis of Acetylcysteine Combined with Meropenem in the Treatment of Severe Pneumonia

PANG Weiling; WANG Rui; LIANG Shuhua

doi:10.14033/j.cnki.cfmr.2026.005.015

Abstract：Objective:To explore the clinical effect of acetylcysteine combined with meropenem in the treatment of severe pneumonia.Method:60 patients with severe pneumonia admitted to Suixi County People's Hospital from October 2023 to October 2024 were selected and divided into two groups.The control group(n=30)was treated with meropenem alone,while the experimental group(n=30)was given acetylcysteine on the basis of meropenem.The clinical efficacy,inflammatory indicators,pulmonary function indicators,oxygenation index and adverse reactions were compared between the two groups.Result:The total effective rate of treatment in the experimental group(93.33％)was higher than that in the control group(73.33％)(P＜0.05).After treatment,the levels of C-reactive protein(25.37±8.75 mg/L vs 45.83±12.41 mg/L),white blood cell count[(8.47±1.68 × 109/L vs 11.26±2.35 × 109/L)],interleukin-6(42.32±12.61 pg/mL vs 68.59±18.78 pg/mL),procalcitonin(2.13±0.82 ng/mL vs 4.61±1.59 ng/mL)and tumor necrosis factor-α(28.91±8.39 pg/mL vs 48.28±11.47 pg/mL)in the experimental group were all lower than those in the control group.The peak expiratory flow and oxygenation index of the experimental group after treatment were higher than those of the control group(P＜0.05).There were no significant differences in mortality(3.33％vs 10.00％)and incidence of adverse reactions(10.00％vs 16.67％)between the two groups(P＞0.05).The mechanical ventilation time in the experimental group(5.22±1.15 days)was shorter than that in the control group(7.84±1.09 days)(P＜0.05).Conclusion:The combined application of acetylcysteine and meropenem in the treatment of severe pneumonia can not only effectively improve the clinical therapeutic effect,but also alleviate the inflammatory response,improve pulmonary function,shorten the duration of mechanical ventilation,and has good safety.