Prediction of Coronary Artery Lesions in Children with Kawasaki Disease by Serum 25-(OH)D3,YKL40,NT-proBNP and sST2

JI Xiaolan; JIANG Lei

doi:10.14033/j.cnki.cfmr.2026.05.002

Abstract：Objective:To explore and analyze the predictive value of serum 25-hydroxy vitamin D3[25-(OH)D3],human chitinase protein-40(YKL40),N-terminal pro-B-type natriuretic peptide(NT-proBNP),and Soluble growth stimulation expressed gene 2(sST2)for the risk of coronary artery lesions in children with Kawasaki disease.Method:Clinical data of 42 children with Kawasaki disease(designated as the study group)admitted to Suzhou Wujiang Children's Hospital between October 2022 and September 2024,and 45 healthy children(designated as the control group)who underwent routine physical examinations during the same period,were retrospectively analyzed.Based on the echocardiography results of the study group,they were further divided into a coronary artery lesion group(18 cases)and a non-coronary artery lesion group(24 cases).Serum markers were compared between the study group and the control group to assess their value in predicting the risk of coronary artery lesions.Result:Serum 25-(OH)D3 levels in the study group were lower than those in the control group,while YKL-40,NT-proBNP,and sST2 levels were significantly higher(P＜0.05).Within the study group,the coronary artery lesion subgroup exhibited higher serum levels of YKL-40,NT-proBNP,and sST2,and lower levels of 25-(OH)D3 compared to the non-coronary artery lesion subgroup(P＜0.05).Serum 25-(OH)D3 level showed a negative correlation with the presence of coronary artery lesions(P＜0.05),whereas YKL-40,NT-proBNP,and sST2 levels showed positive correlations(P＜0.05).The areas under the curve(AUCs)for predicting coronary artery lesion risk were 0.921 for 25-(OH)D3,0.931 for YKL-40,0.745 for NT-proBNP,and 0.963 for sST2.Conclusion:The levels of serum 25-(OH)D3,YKL40,NT-proBNP,and sST2 are closely related to coronary artery lesions in children with KD.Combined detection is helpful for the early clinical identification of high-risk populations of coronary artery lesions in children with KD.