To Compare the Result of High-Dose Dual Therapy and Bismuth Quadruple Therapy in the Treatment of Helicobacter Pylori Infection
WU Jialing
JI Weibiao
Abstract：Objective:To compare the efficacy of high-dose bimodal therapy versus bismuth-based quadruple therapy in treating Helicobacter pylori(H.pylori)infection.Method:200 H.pylori patients admitted to Jieyang People's Hospital from July 2022 to June 2024 were selected as the study objects and randomly assigned to a control group(bismuth-based quadruple therapy)and a trial group(high-dose bimodal therapy).Both groups had equal sample sizes.The trial group received high-dose bimodal therapy,while the control group received bismuth-based quadruple therapy.Treatment outcomes were evaluated through H.pylori eradication rates,medication adherence,and adverse reaction incidence.Results:The trial group demonstrated significantly higher eradication rates than the control group(P>0.05).Adherence metrics showed lower rates of poor compliance in the trial group compared to the control group,while moderate and good compliance scores were significantly higher(P<0.05).Adverse reaction rates were also significantly lower in the trial group.Conclusion:Both bismuth-based quadruple therapy and high-dose bimodal therapy demonstrated effective H.pylori treatment.Although the high-dose bimodal therapy achieved slightly higher eradication rates,it showed superior compliance improvement and reduced adverse reaction incidence compared to the bismuth-based quadruple therapy.
Keywords：Helicobacter pyloriInfectionHigh-dose dual therapyBismuth quadruple therapyEradication rateCompliance
Publication Date：2025-11-15
Online Publishing Date：2025-12-17(First online date of this platform, not the publication date of the document)
Pages：4( 49-52 )