Comparison of the Influence of Different Doses of Aminophylline for Neurological Function and Postoperative Awakening Effect of Children with General Anesthesia
LIN Qinglian
TANG Shuting
HUANG Shengchun
Abstract：Objective:To investigate the influence of different doses of aminophylline for neurological function and postoperative awakening effect of children with general anesthesia.Method:100 children with general anesthesia in Yong'an Municipal Hospital from January 2024 to December 2024 were divided into group A and group B,with 50 cases in each group by the method of random number.Group A were treated with aminophylline with the dose of 2 mg/kg,and group B were reated with aminophylline with the dose of 4 mg/kg.Then the extubation time,wake-up time,Observer's Assessment of Alertness/Sedation Scale(OAA/S score)at 20 min and 30 min after extubation,the adverse reaction rates,hemodynamics[mean arterial pressure(MAP)and heart rate(HR)]and neurological function indexes[serum neuron-specific enolase(NSE)and S100 Calcium Binding Protein B(S100B)]before and after the treatment of two groups were compared.Result:The extubation time,recovery time,and OAA/S scores at 20 min and 30 min after extubation in group B were significantly better than those in group A,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions,the hemodynamic indicators before medication,5 min after medication,and 15 min after medication of the two groups were compared(P>0.05).The neurological function indicators of group B 6 h,12 h and 24 h after medication were lower than those of group A,and the difference was statistically significant(P<0.05).Conclusion:Aminophylline at a dose of 4 mg/kg positively influences neurological function and postoperative awakening in children under general anesthesia and demonstrates a commendable safety profile,indicating its significant application value.
Keywords：Application doseAminophyllineGeneral anesthesiaChildrenNeurological functionPostoperative awakening
Publication Date：2025-11-05
Online Publishing Date：2025-11-27(First online date of this platform, not the publication date of the document)
Pages：4( 40-43 )