The Effect of Tacrolimus Ointment Combined with Narrowband UVB on Patients with Atopic Dermatitis
DAI Yalan
CHEN Yu
FANG Yihong
Abstract：Objective:To investigate the effects of tacrolimus ointment combined with narrowband UVB therapy on patients with atopic dermatitis.Method:A retrospective analysis of clinical data from 80 patients with atopic dermatitis admitted to Shishi Hospital in Fujian Province between June 2021 and June 2023 was conducted.Based on different treatment regimens,patients were divided into a control group and an experimental group,each comprising 40 cases.The control group received treatment with tacrolimus ointment,while the experimental group received the same treatment combined with narrowband medium-wave ultraviolet therapy.Before and after treatment,the atopic dermatitis scoring system(SCORAD)score,skin lesion repair status[exercise-associated skin injury(EASI)score],and incidence of adverse reactions were contrasted across the two groups.Result:Subsequent to therapy,a statistically significant difference in SCORAD and EASI scores was found between the two groups,favoring the experimental intervention(P<0.05).The adverse reaction rates were comparable between the groups,with no statistically significant differences(P>0.05).Conclusion:Combination therapy with tacrolimus and narrowband UVB therapy demonstrates favorable efficacy in patients with atopic dermatitis,effectively reducing the extent and severity of skin lesions while accelerating recovery,with a high safety profile.
Keywords：Tacrolimus ointmentNarrow spectrum ultraviolet radiationAtopic dermatitis
Publication Date：2025-10-25
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：4( 70-73 )