The Efficacy and Safety of Yangxue Fuzheng Prescription in Patients with Schizophrenia

CHEN Ting; QIAN Kejia; TANG Jianping

doi:10.14033/j.cnki.cfmr.2025.29.009

Abstract：Objective:To explore the improvement effect of the Yangxue Fuzheng Formula combined with antipsychotic drugs on the adverse reactions of antipsychotic drugs in patients with schizophrenia.Method:A total of 90 patients with schizophrenia who were treated at the Fourth People's Hospital of Zhangjiagang City from April 2023 to April 2024 were selected and randomly grouped by random number table method,with 45 cases in each group.The control group received conventional antipsychotic drug treatment,while the observation group was combined with the Yangxue Fuzheng Formula.The treatment course was 12 weeks.The changes in the Positive and Negative Symptom Scale(PANSS)scores and the total clinical effectiveness of the two groups were compared.At the same time,the changes in basic biochemical indicators such as liver and kidney functions and adverse reactions of patients before and after treatment in the two groups were also compared.Result:Compared with the control group,the observation group had a higher total clinical effective rate and a lower incidence of adverse reactions,and the difference was statistically significant(P<0.05).After treatment,the PANSS score of the observation group was lower than that of the control group,and the levels of basic biochemical indicators such as liver function and kidney function were higher.The difference was statistically significant(P<0.05).Conclusion:The combination of Yangxue Fuzheng Formula and antipsychotic drugs in the treatment of schizophrenia can not only significantly improve the mental symptoms of patients,but also effectively reduce liver and kidney function damage and other adverse reactions caused by antipsychotic drugs.