Effect of rhEGF Combined with Sodium Hyaluronate Eye Drops on Dry Eye after Phacoemulsification of Cataract
ZHANG Shaobin
Abstract：Objective:Evaluating the therapeutic efficacy of recombinant human epidermal growth factor(rhEGF)in synergistic combination with sodium hyaluronate for the management of post-phacoemulsification dry eye(PKPD).Method:The clinical cases of 100 PKPD patients admitted to Fuzhou First General Hospital across from September 2022 to September 2024 were selected.The study adopted the random number table method for grouping.The observation group and the control group each included 50 patients.The control group was patients treated with sodium hyaluronate eye dreps while the intervention group was treated with rhEGF on the basis of controll group.Tear film stability,the condition of corneal epithelial defect,condition,tear secretion,response rate and adverse reaction were assessed.Result:The control group exhibited significantly longer duration of ocular dryness,burning sensation,eye pain,and photophobia symptoms compared to the observation group,with statistically significant differences(P<0.05).Pretreatment assessments showed no significant intergroup differences in tear film stability,corneal epithelial defect status,disease severity,or tear secretion function(P>0.05).Post-treatment evaluations revealed significantly greater reductions in Ocular Surface Disease Index(OSDI)and fluorescein staining(FL)scores,along with more substantial improvements in Schirmer's test(SIt)and tear film breakup time(BUT)in the observation group versus controls(P<0.05).Efficacy analysis demonstrated a significantly higher treatment response rate in the observation group(98.00%)compared to the control group(86.00%)(P<0.05).Safety assessment indicated no statistically significant difference in the incidence of local reactions including eyelid itching,conjunctival congestion,and ocular redness between groups(P>0.05).Conclusion:The dual-action mechanism of rhEGF and sodium hyaluronate promotes more rapid clinical symptom abatement in affected patients,alleviate the condition,repair corneal epithelial defects,enhance tear secretion function,prolong tear film break-up time,and has good therapeutic effect and high safety.
Keywords：CataractPost phacoemulsification dry eye syndromeRecombinant human epidermal growth factorSodium hyaluronate eye dropsTear secretion function
Publication Date：2025-09-15
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：4( 47-50 )