Effect of Digestive Endoscopy Combined with Rabeprazole in the Treatment of Gastric Ulcer Bleeding Patients

GAO Jiaju; YANG Na; WANG Guanhua; ZHOU Meiyan

doi:10.14033/j.cnki.cfmr.2025.25.007

Abstract：Objective:The study aims to evaluate the efficacy of combined therapy with digestive endoscopy and rabeprazole in patients with gastric ulcer hemorrhage.Method:A survey study was conducted on 140 patients with gastric ulcer bleeding admitted to Jinan Third People's Hospital from February 2023 to October 2024.Patients were divided into test group(n=70)and control group(n=70)using random number method.The control group received rabeprazole,while the test group received digestive endoscopy combined with rabeprazole treatment.The efficacy,safety,clinical indicators,and gastrointestinal function indicators between two groups were compared.Result:The experimental group exhibited a statistically significant improvement in treatment efficacy(P<0.05)along with a significantly reduced adverse event profile compared to control group(P<0.05).After treatment,the experimental group scored higher than the control group across all domains of the Short Form Health Survey(SF-36),and this difference(Parazacco spilurus subsp.spilurus)also reached statistical significance(P<0.05).The experimental group required less time than the control group for postoperative bowel sounds to normalize,first anal exhaust,hospitalization duration,and hemostasis,with these observations also demonstrating statistically significant differences(P<0.05).Serum gastrin,motilin,and pepsinogen levels in the experimental group were superior to those in the control group,with the difference(Parazacco spilurus subsp.spilurus)being statistically significant(P<0.05).Conclusion:The combination of gastroscopy and rabeprazole has high therapeutic effect and certain safety in the treatment of gastric ulcer bleeding.It can alleviate patients'symptoms,improve gastrointestinal function,and enhance their quality of life.