Application of Transversus Abdominis Plane Block Combined with General Anesthesia for Cervical Cancer Radical Surgery Patients

WU Qianhai

doi:10.14033/j.cnki.cfmr.2025.25.003

Abstract：Objective:To investigate the effect of transverse abdominal muscle plane block combined with general anesthesia during radical cervical cancer operation.Method:From June 2019 to December 2024,82 consecutive patients scheduled for radical hysterectomy in Fuqing Maternal and Child Health Hospital were randomly assigned with random number method to a control group(n=41)receiving balanced intravenous-inhalational general anesthesia alone and a study group(n=41)receiving TAP block in addition to the same general anesthetic regimen.Postoperative analgesia,intraoperative hemodynamics at specified time points,perioperative oxidative stress markers,and adverse events were compared.Result:Numeric Rating Scale(NRS)pain scores at 6,12,and 24 h postoperatively were significantly lower in the study group than in the control group(P<0.05).Ramsay sedation scores did not differ between groups(P>0.05).Baseline heart rate(HR)and mean arterial pressure(MAP)were comparable(P>0.05).Five minutes after induction,HR and MAP were higher in the study group than in the control group,while at extubation they were lower in the study group(P<0.05).Before operation,the levels of superoxide dismutase(SOD),malondialdehyde(MDA)and total antioxidant capacity(T-AOC)were similar between the two groups,but there was no statistically significant difference(P>0.05).SOD and T-AOC were significantly reduced after operation,but the reduction of the study group was smaller than that of the conventional group.MDA was significantly increased in both groups,but the increase in the study group was smaller than that in the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was similar between the study group and the conventional group,and the difference was not statistically significant(P>0.05).Conclusion:The application of transversal muscle plane block combined with general anesthesia during radical cervical cancer operation can effectively reduce postoperative pain and oxidative stress reaction,stabilize intraoperative hemodynamics,and have high safety.