Clinical Efficacy of CRT+SIB Sequential Combined with Whole-Brain Conventional Irradiation for Non-small Cell Lung Cancer Brain Metastases

LU Wei

doi:10.14033/j.cnki.cfmr.2025.23.017

Abstract：Objective:Brain metastases are very common in patients with non-small cell lung cancer,and radiotherapy is one of the important treatment methods.However,the optimal radiotherapy plan remains controversial.This article explores the clinical value of Concurrent Reduced-Field Boost Segmentation(CRT+SIB)combined with sequential whole brain irradiation in the treatment of brain metastases from non-small cell lung cancer(NSCLC),and analyzes the clinical effects of CRT+SIB and sequential whole brain irradiation in the treatment of brain metastases from NSCLC.Method:A total of 100 patients with NSCLC brain metastases admitted to the People's Hospital of Liuhe District,Nanjing City from January 2021 to October 2023 were selected as the research subjects.They were divided into the conventional group(50 cases,treated with conventional whole-brain irradiation)and the observation group(50 cases,treated with sequential combination of CRT+SIB and conventional whole-brain irradiation)according to the radiotherapy methods.The short-term efficacy,incidence of adverse reactions and long-term prognosis of the two groups were compared and analyzed.Result:The effective rate of treatment in the observation group was significantly higher than that in the conventional group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions such as cerebral congestion and edema,alopecia,scalp pigmentation and bone marrow suppression between the two groups(P>0.05).The incidence of adverse reactions such as otitis media and hippocampal function decline in the observation group was lower than that in the conventional group,and the overall survival(OS)within half a year and one year was higher than that in the conventional group.The differences were statistically significant(P<0.05).After treatment,the scores of Piper Fatigue Scale-Revised(PFS-R),Rhodes Index of Nausea and Vomiting(INVR),and Quality of Life Questionnaire(QLQ-C30)in both groups were significantly increased compared with before,and those in the observation group were lower than those in the conventional group,with statistically significant differences(P<0.05).Conclusion:The sequential combined treatment of CRT+SIB and conventional whole-brain irradiation for brain metastases of NSCLC can achieve significant short-term efficacy and safety guarantee,and has a good long-term prognosis.