Effect of Budesonide and Formoterol Fumarate Powder for Inhalation Combined with Azithromycin in the Treatment of Pediatric Bronchial Asthma
HUANG Xiaomei
Abstract：Objective:To investigate the efficacy of Budesonide and Formoterol Fumarate Powder for Inhalation combined with Azithromycin in the treatment of pediatric bronchial asthma(BA).Method:From September 2023 to September 2024,93 cases of children with BA admitted to Putian Children's Hospital were selected and divided into the control group(Budesonide and Formoterol Fumarate Powder for Inhalation,46 cases)and the experimental group(Budesonide and Formoterol Fumarate Powder for Inhalation+Azithromycin,47 cases)by the random number method,and the efficacy,symptom disappearance,airway remodelling indexes,inflammatory indexes,and adverse reactions of the two groups were compared in 2 weeks of treatment.Result:The total effective rate of the experimental group was higher than that of the control group,the time of disappearance of cough,shortness of breath and pulmonary rales was shorter than that of the control group,and the matrix metalloproteinase-3(MMP-3),MMP-9,tissue inhibitor of metalloproteinase-1(TIMP-1),interleukin-6(IL-6),IL-13,and tumor necrosis factor-alpha(TNF-alpha)were lower than that of the control group,and the difference was statistically significant(P<0.05).The difference in adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:The combination of Budesonide and Formoterol Fumarate Powder for Inhalation and Azithromycin is safe and effective in the treatment of children with BA,which can reduce the inflammatory response,inhibit airway remodelling and improve clinical symptoms.
Keywords：Bronchial asthmaBudesonide and Formoterol Fumarate Powder for InhalationAzithromycinInflammatory indexes
Publication Date：2025-08-15
Online Publishing Date：2025-09-10(First online date of this platform, not the publication date of the document)
Pages：4( 34-37 )